Opportunity Information: Apply for RFA CA 18 007
The grant opportunity "Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U01 Clinical Trials Optional)" (RFA-CA-18-007) is a National Cancer Institute (NCI) funding announcement designed specifically for revision applications to existing, currently funded NCI U01 cooperative agreement projects. The central idea is to help active U01 research teams speed up or broaden the impact of their parent projects by adding a new tool, method, or technical approach that was developed with support from NCI's Innovative Molecular Analysis Technologies (IMAT) program. In practical terms, this is not a stand-alone grant for a brand-new project; it is supplemental funding meant to expand the scope or momentum of an already-funded U01 by integrating an IMAT-originated technology that can push the science forward faster than the original plan alone.
A major goal of this FOA is independent validation of emerging IMAT technologies. The NCI is trying to move promising instruments and analytical approaches from development into real-world use by encouraging outside research groups to test them within active cancer research studies. By funding revisions to ongoing U01 projects, NCI is leveraging established infrastructure, samples, datasets, and research teams to evaluate whether a new IMAT-supported technology is robust, reproducible, and genuinely useful for broader cancer research communities. The emphasis is on accelerating suitability and adoption: the revision work should generate evidence that the technology works as intended, adds value, and can be reasonably transferred or scaled for other investigators and contexts.
This opportunity uses the cooperative agreement mechanism (U01), meaning NCI expects an active, collaborative role in the project rather than a hands-off relationship. While the exact nature of that collaboration can vary by award, cooperative agreements typically involve substantial NIH programmatic involvement in areas such as coordination, oversight, milestone tracking, or harmonization with related NCI efforts. The FOA notes that clinical trials are optional, which means applicants can propose work that includes a clinical trial if appropriate, but they are not required to do so. The scientific focus remains on integrating an IMAT-developed approach into the parent U01 project in a way that expands the research questions or accelerates progress.
The announcement sits within the broader IMAT program mission, which is to catalyze interdisciplinary tool-building and methodological innovation for cancer research. This revision-focused FOA reflects that mission by explicitly promoting collaboration across disciplines, such as pairing technology developers and engineering or computational experts with cancer biologists, clinicians, and translational research teams. The expectation is that incorporating novel molecular analysis technologies into active cancer studies can shorten the time from invention to discovery, improve measurement or analytical capabilities, and open up new lines of investigation that were not feasible under the original technical plan.
Key administrative details include that the sponsoring agency is the U.S. Department of Health and Human Services through the National Institutes of Health, specifically NCI. The opportunity is categorized as discretionary funding and is associated with CFDA number 93.394. The FOA was created on December 4, 2017, with an original closing date of September 28, 2018. The award ceiling is listed as $150,000, and NCI anticipated making about three awards, indicating this is a targeted, relatively small program intended to strategically validate and deploy specific technologies rather than fund a large portfolio of projects.
Eligibility is broad and includes many organization types that typically apply to NIH funding, including public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and various levels of government (state, county, city/township, special districts), as well as tribal governments and tribal organizations, and public housing authorities/Indian housing authorities. Despite this broad eligibility, the practical constraint is that applicants must already have an active NCI-funded U01 project suitable for a revision, because the entire mechanism is intended to modify and enhance an existing award rather than initiate a new one.
Overall, the FOA is best understood as a focused accelerator: it provides modest, strategic revision funding to help ongoing NCI U01 teams integrate IMAT-supported technologies, validate them independently in real cancer research settings, and generate the kind of performance and utility evidence that makes a new tool credible and adoptable by the wider research community. The expected outcome is faster scientific progress in the parent study and faster maturation of promising IMAT innovations into broadly useful cancer research technologies.Apply for RFA CA 18 007
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U01 Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394.
- This funding opportunity was created on Dec 04, 2017.
- Applicants must submit their applications by Sep 28, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| Funding Opportunity |
|---|
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trials Optional) Apply for RFA CA 18 006 Funding Number: RFA CA 18 006 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3, Clinical Trial Optional) Apply for RFA DA 18 020 Funding Number: RFA DA 18 020 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Administrative Supplements to NCI Grant and Cooperative Agreement Awards to Support Collaborations with the PDX Development and Trial Centers Research Network (PDXNet)(Admin Suppl - Clinical Trial Not Allowed) Apply for PA 18 496 Funding Number: PA 18 496 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $125,000 |
| Identification of Biomarkers of HIV-1 Pathogenesis and Substance Abuse Comorbidity (R01- Clinical Trial Not Allowed) Apply for RFA DA 18 023 Funding Number: RFA DA 18 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Distance Learning and Telemedicine Grant Program Apply for RUS 18 01 DLT Funding Number: RUS 18 01 DLT Agency: Department of Agriculture, Utilities Programs Category: Education, Health Funding Amount: $500,000 |
| Administrative Supplements to NCI Grant and Cooperative Agreement Awards to Support Collaborations with the Drug Resistance and Sensitivity Network (DRSN)(Admin Supp Clinical Trial Not Allowed) Apply for PAR 18 752 Funding Number: PAR 18 752 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| NCI Community Oncology Research Program (NCORP) Community Sites (UG1 Clinical Trial Required) Apply for RFA CA 18 016 Funding Number: RFA CA 18 016 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Community Oncology Research Program (NCORP) Minority/Underserved Community Sites (UG1 Clinical Trial Required) Apply for RFA CA 18 017 Funding Number: RFA CA 18 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Community Oncology Research Program (NCORP) Research Bases (UG1 Clinical Trial Required) Apply for RFA CA 18 015 Funding Number: RFA CA 18 015 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Approaches to Identify and Care for Individuals with Inherited Cancer Syndromes (U01 Clinical Trial Required) Apply for RFA CA 19 017 Funding Number: RFA CA 19 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HIV/AIDS High Priority Drug Abuse Research (R01 Clinical Trial Optional) Apply for PAS 18 915 Funding Number: PAS 18 915 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Fusion Oncoproteins in Childhood Cancers (FusOnC2) Consortium (U54 Clinical Trial Not Allowed) Apply for RFA CA 19 016 Funding Number: RFA CA 19 016 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,600,000 |
| Administrative Supplements to Cancer Center Support Grants to Strengthen the Research, Training, and Outreach Capacity of the Geographic Management of Cancer Health Disparities Program (Admin Suppl - Clinical Trial Not Allowed) Apply for PA 18 934 Funding Number: PA 18 934 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| The National Drug Abuse Treatment Clinical Trials Network (UG1 Clinical Trial Optional) Apply for RFA DA 19 008 Funding Number: RFA DA 19 008 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| NLM Grants for Scholarly Works in Biomedicine and Health (G13 Clinical Trial Not Allowed) Apply for PAR 19 032 Funding Number: PAR 19 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| Administrative Supplements to Cancer Center Support Grants to Strengthen NCI-Supported Community Outreach Capacity through Community Health Educators of the National Outreach Network (Admin Suppl Clinical Trial Not Allowed) Apply for PA 19 035 Funding Number: PA 19 035 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $125,000 |
| Immuno-Oncology Translation Network (IOTN): Immuno-engineering to Improve Immunotherapy (i3) Centers (U54 Clinical Trial Not Allowed) Apply for RFA CA 19 013 Funding Number: RFA CA 19 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $900,000 |
| HEAL Initiative: Justice Community Opioid Innovation Network (JCOIN) Coordination and Translation Center (U2C Clinical Trial Optional) Apply for RFA DA 19 024 Funding Number: RFA DA 19 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $2,500,000 |
| HEAL Initiative: Justice Community Opioid Innovation Network (JCOIN) Methodology and Advanced Analytics Resource Center (U2C Clinical Trial Not Allowed) Apply for RFA DA 19 023 Funding Number: RFA DA 19 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $2,500,000 |
| NCI Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Not Allowed) Apply for RFA CA 19 029 Funding Number: RFA CA 19 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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